Prof. Dr. Wilfried Dimpfel      10/2007

Publications and Books:
Please click on number (if tagged blue) in order to view the corresponding pdf.file!

1.    Habermann E., and Dimpfel W., Distribution of 125-I-Tetanus Toxin and 125-I-Toxid in Rats with Generalized Tetanus, as Influenced by Antitoxin. Naunyn-Schmiedeberg's Arch. Pharmacol. 276: 327 - 340 (1973).

2.    Habermann E., Dimpfel W., Räker K.O., Interaction of Labelled Tetanus Toxin with Substructures of Rat Spinal Cord in vivo. Naunyn-Schmiedeberg's Arch. Pharmacol. 276: 361 - 373 (1973).

3.    Dimpfel W., Habermann E., Histoautoratiographic Localisation of 125-I-Labeled Tetanus Toxin in Rat Spinal Cord. Naunyn-Schmiedeberg's Arch. Pharmacol. 280: 177 - 182 (1973).

4.    Dimpfel W., Neale J.H., Habermann E., 125-I-Labelled Tetanus Toxin as a Neuronal Marker in Tissue Cultures Derived from Embryonic CNS. Naunyn-Schmiedeberg's Arch. Pharmacol. 290: 329 - 333 (1975).

5.    Neale J.H., Dimpfel W., Movement of Labeled Macromolecules to the Goldfish Optic Tectum following Intraocular Injection of 125-I-Labeled Tetanus Toxin. Experimental Neurology 53: 355 - 362 (1976).

6.    Dimpfel W., Huang R.T.C., Habermann E., Gangliosides in nervous tissue cultures and binding of 125-I-labelled tetanus toxin, a neuronal marker. J Neurochem 29: 329 - 334 (1977).

7.    Dimpfel W., Habermann E., Binding characteristics of 125-I-labelled tetanus toxin to primary tissue cultures from mouse embryonic CNS. J Neurochem 29: 1111 - 1120 (1977).

8.    Bigalke H., Dimpfel W., Kinetics of (3H)-acetylcholine synthesis and release in primary cell cultures from mammalian CNS. J Neurochem 30: 871 - 879 (1978).

9.    Bigalke H., Dimpfel W., Habermann E., Suppression of (3H)-Acetylcholine Release from Primary Nerve Cultures by Tetanus and Botulinum-A Toxin. Naunyn-Schmiedeberg's Arch. Pharmacol. 303: 133 - 138 (1978).

10.    Bijok U., Dimpfel W., Habermann E., and H. Ludwig, Normal and Pseudorabies Virus Infected Primary Nerve Cell Cultures in Scanning Electron Microscopy. Med. Microbiol. Immunol. 167: 117 - 126 (1979).

11.    Dimpfel W., Pierau F.K.- Haider S.G., Electrophysiological Studies on the Effects of the Neurotoxin Apamin in Cultured Neurons. Advances in Cytopharmacol 3: 395 - 399 (1979).

12.    Dimpfel W., Hyperexcitability of cultured central nervous system neurons caused by tetanus toxin. Experimental Neurology 65: 53 - 65 (1979).

13.    Dimpfel W., Rat nerve cell cultures in pharmacology and toxicology. Arch Toxicol 44: 55 - 62 (1980).

14.    Dimpfel W., Pathogenic actions of tetanus toxin. TINS, 04: 80 - 82 (1980).

15.    Dimpfel W., Mammalian nerve cell culture. Methods in Enzymology 77: 162 - 166 (1981).

16.    Dimpfel W., Möller W., Menges U., Ganglioside-induced neurite formation in cultured neuroblastoma cells .in: Gangliosides in Neurological and Neuromular Functionscu, Development, and Repair, Rapport M.M. and Gorio A. (Hrsg.), Raven Press, New York (1981).

17.    Jorgensen O.S., Dimpfel W., Nervous System Specific Protein D2 Associated with Neurite Outgrowth in Nerve Cell Cultures. Jounal Neuroimmunology 2: 107 - 117 (1982).

18.    Dimpfel W., Differential Distribution of Gangliosides in Nerve-Cell Cultures. Cellular and Molecular Neurobiology Vol. 2, Nr. 2, 105 - 113 (1982)

19.    Haider S.G., Bijok U., Dimpfel W., Pierau Fr.K., Morphological and Electrophyiological Aspects of Dissociated Cultures of Rat CNS. Arch Toxcol 54: 343 - 352 (1983).

20.    Dimpfel W., Otten U., Studies of gangliosides in diverse nerve cell cultures. in: Ganglioside structurem function, and biomedical potential Advances in Experimental Medicine and Biology, Ledeen R.W., Yu R.K., Rapport M.M., Suzu ki K. (Hrsg.), 174: 525 - 534, Plenum Press New York and London (1984).

21.    Dimpfel ,W., Decker, H., Classification of Drugs by Stereotactic Recording of Focal Brain Activity in the Rat (Stereo-EEG). Neuropsychobiology 12, 188 - 185  (1984).

22.    Dimpfel, W., Decker, H., Classification of Sulpiride, Clozapine and Haloperidol by Toposelective Recording from Different Brain Structures in the Immobilized Rat (Stereo-EEG). Neuropsychobiology 14, 157 - 164 (1985).

23.    Dimpfel, W., Drug-induced field potential changes in dopaminergic target areas after electrical stimulation of the rat mesencephalon. Neuropsychobiology 14, 42 - 52  (1985).

24.    Dimpfel, W., Spüler, M., Nickel, B., Radioelectroencephalography (Tele-Stereo-EGG) in the rat as a pharmacological model to differentiate the cental action of flupirtine from that of opiates, diazepam and phenobarbital. Neuropsychobiology 16, 163 - 168 (1986).

25.    Dimpfel, W., Spüler, M., Nickel, B., Tibes, U., "Fingerprints" of Central Stimulatory Drug Effects by Means of Quantitative Radioencephalography in the Rat (Tele-Stereo-EEG). Neuropsychobiology 15, 101 - 108 (1986).

26.    Dimpfel, W., Spüler, M., Tüllner H.-U.,  Effects of Gangliosides on Nerve Conduction Velocity during Diabetic Neurophathy in the Rat. Gangliosides and Modulation of Neuronal Fuction, Nato ASI Series 7, (1987).

27.    Dimpfel, W., Spüler, M., Tüllner H.-U., Effect of Gangliosides on Nerve Conduction Archives inter Velocity during Diabetic Neuropathy in the Rat. Archives internat. de Pharmacodyn. et de Thérapie 287, 211-223 (1987).

28.    Dimpfel, W., Spüler, M., Koch, R., Schatton, E., Radioelectroencephalographic comparison of memantine with receptor-specific drugs acting on dopaminergic transmission in freely moving rats.  Neuropsychobiology 18, 212 - 218  (1987).

29.    Dimpfel, W., Spüler, M., Neurophysiologische Studien zum Aktivitätsprofil von Memantin. In: "Memantine-Workshop: Expertengespräche (1988). Budapest, W. Zuckschwerdt Verlag, München, Bern, Wien, San Francisco.

30.    Dimpfel, W., Spüler, M., Borbe, H.-O., Monitoring of the effects of antidepressant drugs in the freely moving rat by radioelectroencephalography (Tele-Stereo-EEG). Neuropsychobiology 19, 116 - 120 (1988).

31.    Dimpfel, W., Spüler, M., Boke, D., Erhöhte Noradrenalinempfindlichkeit im ZNS der Ratte nach chronischer Applikation einer B-Vitaminkombination. In: Klinische Bedeutung von Vitamin B1, B2, B12, in der Schmerztherapie. N. Zöllner, H. Fassl, I. Jurna, K.-F. Pietrzik, M. Schattenkirchner (Hrsg.) Steinkopf-Verlag, Darmstadt  (1988)

32.    Dimpfel, W., Spüler, M., Nickel, B., Dose and time dependent action of morphine, tramadol and flupirtine as studied by radioelectroencephalography in the freely behaving rat. Neuropsychobiology  20, 164 - 168  (1988).

33.    Dimpfel, W., Spüler, M., Menge,  H.G., Effects of the antiparkinson drug budipine on EEG activity in freely moving rats. Arzneimittel-Forschung/Drug Research 39 (1) 5, 560 - 563  (1989).

34.    Dimpfel, W., Spüler, M., Nichols, D.-E.,  Hallucinogenic and stimulatory amphetamine derivates: Finger-printing DOM, DOI, DOB, MDMA and MBDB by spectral analysis of brain field potentials in the freely moving rat ( Tele-Etereo-EEG). Psychopharmacology 98, 297 - 303 (1989).

35.    Dimpfel, W., Schindler, U., Spüler, M., Radioelectroencephalographic Characterization of Tenilsetam (CAS 997), a Putative Nootropic Compound, in the Freely Moving Rat (Tele-Stereo-EEG). Drug Development Research 18, 217 - 227  (1989).

36.    Dimpfel, W., Spüler, M., Borbe, D., Influence of Repeated Vitamin B Administration on the Frequency Pattern Analysed from Rat Brain Electrical Activity (Tele-Stereo-EEG). Klinische Wochenschrift 68, 136 - 141 (1990).

37.    Dimpfel, W., Spüler, M., Dizocilpine (MK 801), ketamine and phencylcidine: Low doses affect brain field potentials in the feely moving rat in the same way as activaton of dopaminergic transmission. Psychopharmacology 101, 317 - 323 (1990).
   
38.    Dimpfel, W., Spüler, M., Pierau F.-K., Ulrich,  H., Thioctic Acid Induces Dose-Dependent Sprouting of Neurites in Cultured Rat Neuroblastoma Cells. Pharmacol. Ther. 14, 193 - 199 (1990).

39.    Dimpfel, W.,  Spüler, M., Dalhoff, A., Hofmann, W., Schlüter , G., Hippocampal Activity in the Presence of Quinolones and Fenbufen in Vitro. Antimicrobial Agents and Chemotherapy  June, 1142 - 1146 (1991).

40.    Dimpfel, W., Spüler, M., Netter, P., Wedekind, W., Wirkung von Cyclandelat auf das ZNS - Eine doppelblind, placebo-kontrollierte Studie an gesunden Probanden. Klin. Wochenschrift 69, 313 - 319 (1991).

41.    Dimpfel, W.,  Spüler, M., Wessel, K., Different neuroleptics show common dose and time dependent effects in quantitative field potential analysis in freely moving rats. Psychopharmacology 107, 195 - 202 (1992).

42.    Dimpfel, W., Wedekind, W., Spüler, M.,  Field potential analysis in the feely moving rat during actions of cyclandelate or flunarizine. Pharmacological Research 25, 287 - 297 (1992).

43.    Dimpfel, W., Schober F., Spüler, M.,  Influence of Caffeine on Human EEG under Resting Conditions and while Performing Mental Arithmetic.Klin. Pharmakol. Akt. 3 Jahrg., Heft 1 , 71-72 (1992).

44.    Dimpfel, W., Schober, F., Spüler, M., The Influence of Caffeine on Human EEG under Resting Conditions and during Mental Loads. The Clinical Investigator 71, 197 - 207 (1993).

45.    Dimpfel W., Dalhoff B., Hofmann W., Schlüter G.,  Electrically evoked potentials in the rat hippocampus slice in the presence of aminophylline alone and in combination with quinolones. European Neuropsychopharmacology 4, 151 - 156 (1994).

46.     Dimpfel W., Schober F., Wedekind W., Kleinbloesem C., Coors C., Nachweis pharmakokinetischer-pharmakodynamischer Beziehungen mittels Pharmako-EEG bei gesunden Probanden nach Verabreichung von Cyclandelat. Arzneim.-Forsch./Drug Res. 44 (II), 9, 999 - 1004 (1994)

47.    Dimpfel W., Hofmann H.-C. Central Nervous System Monitoring; Reduction of Information Content of Quantitative Electroencephalograms for Continuous On-Line Display During Anaesthesia.. In: Schulte am Esch J., Kochs E., (Hrsg) Central Nervous System Monitoring in Anesthesia and Intensive Care, Springer Verlag ,Berlin, (1994)

48.    Dimpfel W. Pharmakologische Aspekte der Analgosedierung. In: Das traumatisch-hirnorganische Psychosyndrom Bauer B. L., Springer Verlag, Berlin (1994)

49.    Schellenberg, R., Milch, W., Schwarz, A., Schober, F. and Dimpfel, W., Quantitative EEG and BPRS-data following Haldol-Deconoate® administration in schizophrenics. J. Clin. Psychopharmacol. 9, 17 - 24 (1994).


50.    Schober, F., Schellenberg, R., Dimpfel, W., Neue Wege zur Beurteilung der mentalen Leistungsfähigkeit mittels simultaner topographischer Elektroenzephalometrie und Psychometrie in der Pharmakologie. Arzneim.-Forsch./Drug Res. 44 (II), 12: 1285 - 1295 (1994)

51.    Pietzko A., Dimpfel W., Schwantes U., Topfmeier P., Influences of trospium chloride and oxybutynin on quantitative topographical EEG in healthy volunteers. Eur J Clin Pharmacol 47: 337 - 343 (1994)

52.    Todorova A., Dimpfel W., Multiunit activity from the A9 and A10 areas in rats following chronic treatment with different neuroleptic drugs. European Neuropsychopharmacology 4: 491 - 501 (1994)

53.    Dimpfel W. Effects of Memantine on Synaptic Transmission in the Hippocampus in vitro. Arzneim.-Forsch./Drug. Res. 45 (I), 1, 1 - 5 (1995)

54.    Schober, F., Schellenberg, R., Dimpfel, W., Reflection of mental exercise in the dynamic quantitative topographical EEG. Neuropsychobiology  31: 98 - 112 (1995)

55.    Schellenberg R., Todorova A., Dimpfel W., Schober F., Pathophysiology and psychopharmacology of dementia - a new study design. Diagnosis - comprising subjective and ovjective criteria. Neuropsychobiology 32: 81 - 97 (1995)

56.    Dimpfel W., Hofmann H.-C., Mehrdimensionale Dokumentation des Schlafes auf der Grundlage der Frequenzanalyse. In: Mayer G. (Hrsg.) Jahrbuch Schlafmedizin in Deutschland 1994, MMV Medizin Verlag, München (1995)

57.    Schellenberg R., Todorova A., Hofmann H.-C., Dimpfel W., Schober F., Differentiation of demented patients and healthy subjects by means of quantitative-topological EEG - a classifcation approach. Alzheimer's Research 1: 23 - 28 (1995)

58.    Reiser H.-P., Dimpfel W., Schober F., The Influence of Electromagnetic Fields on Human Brain Activity. Eur. J. Med. Res. 1: 27 - 32 (1995)

59.    Dimpfel W., Hofmann H.C., Prohaska A., Schober F., Schellenberg R. Source Density Analysis of Funcitonal Topographical EEG: Monitoring of Cognitive Drug Action. Eur. J. Med. Res. 1: 283 - 290 (1996)

60.    Dimpfel W., Effect of thioctic acid on pyramidal cell responses in the rat hippocampus in vitro. Eur.J.Med.Res. 1:523-527 (1995/96

61.    Schellenberg R., Todorova A., Wedekind W., Schober F., Dimpfel W. Pathophysiology and psychopharmacology of dementia - A new study design. 2. Cyclandelate Treatment - a Placebo-Controlled Double-Blind Clincal Trial. Neuropsychobiology 35: 132 - 142 (1997)

62.    Todorova A., Hofmann H.C., Dimpfel W. A New Frequency Based Automatic Sleep Analysis - Description of the Healthy Sleep. Eur. J. Med. Res. 2: 185 - 197 (1997)

63.    Sauer S., Schellenberg R., Hofmann H.C., Dimpfel W. Functional Imaging of Headache - First Steps in an Objective Classification of Migraine. Eur. J. Med. Res. 2: 367 - 376 (1997)63.

64.    Dimpfel W., Schombert L., Central Action of Hyperici Herba Cum Flore Extractum Siccum In Freely Moving Rats.  Eur. J. Med. Res.  2:491-496 (1997)

65.    Dimpfel W., Schober F., Mannel M. Effects of a Methanolic Extract and a Hyperforin-Enriched CO2 Extract of St. John`s Wort (Hypericum perforatum) on Intracerebral Field Potentials in the Freely Moving Rat (Tele-Stereo-EEG).  Pharmacopsychiat. 31 (Suppl.): 30-35 (1998)

66.    Todorova A., Schellenberg R., Hofmann H.C., Dimpfel W. Effect of the  Ecternal Nasal Divator Breathe Right® on snoring. Eur. J. Med. Res. 3: 367-379 (1998)

67.    Schellenberg., SauerS., Dimpfel W. Pharmacodynamic Effects of two Different Hypericum Extracts in Healthy Volunteers Measured by Quantitative EEG. Pharmacopsychiat. 31(suppl.): 44-53 (1998).

68.    Dimpfel W., Hofmann H.-C., Schober F., Todorova A.  Validation of an EEG-Derived Spectral Frequency Index (SFx) for continuous monitoring of sleep depth in humans.  Eur. J. Med. Res. 3: 453-460 (1998)

69.    Dimpfel W.,  Todorova A., Vonderheit-Guth B.  Pharmacodynamic properties of St. John´s Wort. A Single blind neurophysiological study in healthy subjects comparing two commercial preparations  Eur. J. Med. Res. 4: 303-312 (1999)

70.    Renz D., Dimpfel W.,  Schober F., Karliczek GF.  Bedeutung des Spektralen Fequenzindex (SFx) zur Quantifizierung der Schlaftiefe während der Narkoseeinleitung.  Acta Anaesthesologica Helvetida  (No.2): 9-11 (1999)

71.    Vonderheid-Guth B., Todorova A., Wedekind W., Dimpfel W.  Evidence for neuronal dysfunction in migraine: concurrence between specific qEEG findings and clinical drug response - a retrospective analysis. Eur. J. Med. Res. 5: 473-483 (2000)

72.    Dimpfel W., Schober F.  Norepinephrine, EEG theta waves and Sedation in the rat. Brain Pharmacology, 2001,1, 89-97

73.    Dimpfel W., Vonderheid-Guth B., Wedekind W. Das quantitative EEG als elektrischer "Fingerprint" von Phytopharmaka bei Ratte und Mensch. Zeitschrift für Phytotherapie 22, 22-27 (2001)

74.    Vonderheid-Guth B., Todorova A., Brattström A., Dimpfel W. Pharmacodynamic Effects of Valerian and Hops Extract Combination (ZE 91019) on the Quantitative-Topographical EEG in Healthy Volunteers. Eur. J. Med. Res. 5: 139-144 (2000)

75.    Todorova A., Vonderheid-Guth B. , Dimpfel W. Effects of Tolterodine, Trospium Chloride, and Oxybutynin on the Central Nervous System J Clin Pharmacol 2001; 41. 636-644

76.    Dimpfel W., Wedekind W., Keplinger I.  Efficacy of Dimethylaminoethanol (DMAE) Containing Vitamin-mineral Drug Combination on EEG Patterns in the Presence of Different Emotional States. Eur. J. Med. Res ( 2003 ) 8: 183-191

77.    Dimpfel W., Wedekind W., Keplinger I. Gender Difference in Electrical Brain Activity during Presentation of Various Film Excerpts with Different Emotional Content.  Eur. J. Med. Res ( 2003 ) 8: 192-198

78.    Dimpfel W., Preclinical Data Base of Pharmaco-specific Rat EEG Fingerprints (Tele-Stereo-EEG) Eur. J. Med. Res ( 2003 ) 8: 199-207

79.   Dimpfel W. Brain mapping: its use in drug development. Innovations in Clinical Trials, 2004: 24 - 29

80.   Dimpfel W., Pischel I., Lehnfeld R. Effects of Lozenge containing Lavender Oil, Extracts from Hops, Lemon Balm and Oat on Electrical Brain Activity of Volunteers.(2004) Eur J Med Res 9: 423-431

81.    Dimpfel W., Pharmacological modulation of cholinergic brain activity and its reflection in special EEG frequency ranges from various brain areas in the freely moving rat (Tele-Stereo-EEG) (European Neuropsychopharmacology 15 (2005) 673-882

82.    Dimpfel W, Kler A, Kriesl E, Lehnfeld R und Keplinger-Dimpfel I.K.,  Neurophysiological characterization of functionally active drink containing extracts of ginkgo and ginseng by source density analysis of the human EEG (Nutritional Neuroscience (2006) Vol 9, Number 5-6 October 2006 (213-224)

83.    Dimpfel W., Different anticonvulsive effects of hesperidin and is aglycone hesperetin on electrical activity in the rat hippocampus in-vitro (Journal of Pharmacy and Pharmacology JPP (2006), 58: 375-379)

84.    Dimpfel W., Brattström, Koetter U, Central action of a fixed valerian-hops extract combination (Ze 91019) in freely moving rats Eur. J. Med. Res 11 (2006) 496-500

85.  Dimpfel W, Kler A, Kriesl E, Lehnfeld R und Keplinger-Dimpfel I.K., Theogallin and L-theanine as active ingredients in decaffeinated green tea extract: I. Electrophysiological characterization in the rat hippocampus in-vitro Journal of Pharmacy and Pharmacology JJP (2007) 59:1131-1136

86.    Dimpfel W, Kler A, Kriesl E, Lehnfeld R und Keplinger-Dimpfel I.K., Theogallin and L-theanine as active ingredients in decaffeinated green tea extract: II. Characterization in the freely moving rat by means of quantitative field potential analysis Journal of Pharmacy and Pharmacology JJP (2007) 59:10 1397-1403

87.    Dimpfel W, Akute Wirksamkeit eines Baldrian Trockenextraktes auf die Schlaftiefe beim Menschen. Eine doppel-blinde, randomisierte, placebo-kontrollierte Studie im parallel Design  Zeitschrift für Phytotherapie (2007); 28:7-15

88.    Dimpfel W, Reflection of atypicality of antipsychotic drugs by a late decrease of striatal alpha1 spectral power in the electropharmacogram of freely moving rats (2007) British J Pharmacol Aug 13: [Epub ahead of print]

89.    Dimpfel W, Kler A, Kriesl E, Lehnfeld R und Keplinger-Dimpfel I.K., Source density analysis of human EEG after ingestion of a drink containing containing decaffeinated extract of green tea enriched with L-theanine and Theogallin ( 2007) Nutritional Neuroscience 10: 169-180

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