index

Brain Research

Pharma

  Contract Research Organisation using Electrophysiological Technologies

Contact    Staff     Literature   Poster   Patients   News   Links

The key question in drug development is: what kind of clinical indication can I expect with my new drug entity? Classically quite a number of disease specific animal tests have to be performed. Knowing that any drug acting on the brain modulates the electrical activity and that similar drugs change the frequency pattern of the brain`s activity in a similar manner, recording of the EEG provides all the information needed. With a reference data base of about 200 preparations, classification of a new compound can be performed within weeks saving a lot of money. All pharmacological textbook indication are covered. Please find more details and examples below.

Primary Nervous Tissue Culture with electrically active neurons.

Field potentials recorded from the depth of the brain contain information on ion channel activities, neurotransmitter actions and determine behaviour. On an intermediate level between molecular events and behaviour, frequency analysis of these potentials provide solid information on the effectiveness of drugs.

We are certified for the conduction of clinical studies aiming at the characterization of drug effects as well as the substantiation of health claims with respect to nutraceuticals. Since the electric activity of the brain determines our cognitive, emotional and motor capabilities, a new special methodology of quantitative EEG analyis provides all information needed to find out about the action of drugs on the brain. Surrogate parameters for mood, several cognitive features like memory, concentration or mental fitness are available now and have been used in earlier studies. For more details see information below.

(Please double click picture to see real time brain mapping during without and with mental work)

Spectral changes during mental work

Spectral frequency changes in the presence of mental work

On line real time brain mapping during watching TV (takes more time)

Source density analysis of the EEG provides similar information as field potentials in deeper brain structures. Symphony of neurotransmitter activity is mirrored in particular frequencies and determine cognition, emotion and motor activities. This non-invasive technology allows for objective determination of surrogate parameters of clinical drug action .

CEO: Ingrid K. Keplinger-Dimpfel
Clinical Consulting: Dr. Winfried Wedekind
Scientific Consulting: Prof. Dr. Wilfried Dimpfel, Justus-Liebig-University Giessen

D 35578 Wetzlar / Germany Sportsparkstr. 9
Phone: +49-6441-2002030 Fax: +49-6441-2002039
HRB 5201 Amtsgericht Wetzlar; Steuernummer 020 240 10935; VAT.Nr. DE230207376

Preclinical Drug Profiling The key question in drug development is: what kind of clinical indication can I expect with my new drug entity? Classically quite a number of disease specific animal tests have to be performed. Knowing that any drug acting on the brain modulates the electrical activity and that similar drugs change the frequency pattern of the brain`s activity in a similar manner, recording of the EEG provides all the information needed. With a reference data base of about 200 preparations, classification of a new compound can be performed within weeks saving a lot of money. All pharmacological textbook indication are covered. Please find more details and examples below. . Primary Nervous Tissue Culture with electrically active neurons. Field potentials recorded from the depth of the brain contain information on ion channel activities, neurotransmitter actions and determine behaviour. On an intermediate level between molecular events and behaviour, frequency analysis of these potentials provide solid information on the effectiveness of drugs.		Clinical Studies We are certified for the conduction of clinical studies aiming at the characterization of drug effects as well as the substantiation of health claims with respect to nutraceuticals. Since the electric activity of the brain determines our cognitive, emotional and motor capabilities, a new special methodology of quantitative EEG analyis provides all information needed to find out about the action of drugs on the brain. Surrogate parameters for mood, several cognitive features like memory, concentration or mental fitness are available now and have been used in earlier studies. For more details see information below. (Please double click picture to see real time brain mapping during without and with mental work) On line real time brain mapping during watching TV (takes more time) Source density analysis of the EEG provides similar information as field potentials in deeper brain structures. Symphony of neurotransmitter activity is mirrored in particular frequencies and determine cognition, emotion and motor activities. This non-invasive technology allows for objective determination of surrogate parameters of clinical drug action .
Neuroleptic and anticonvulsant drugs Analgesic and sedative drugs Antidepressant and narcotic drugs Drug profiling by means of discriminant analysis Innovation in developmental drug research		Surrogate parameters for cognition Surrogate parameter for emotion Research into sleep The Sleep Lab Substantiation of Health Claims Evaluation of TV Commercials Brain mapping during exposure to horror film